Il ruolo della vitamina D nell’osteoporosi

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La Vitamina D, nelle sue diverse forme, D2 e D3, è una sostanza ormonale prodotta in gran parte dall’irradiazione della cute da parte dei raggi U.V. ed in misura minore assunta con la dieta.
Il rapporto fra il tessuto osseo e Vitamina D è noto da molto tempo, da quando cioè vennero evidenziati i deleteri effetti prodotti dalla mancanza di luce solare sullo scheletro dei bambini e degli adolescenti, a configurare il ben noto rachitismo infantile. Più recentemente, inconseguenza dell’allungamento della vita media della popolazione, della scarsa abitudine degli anziani ad esporsi al sole e delle loro più ridotte capacità biosintetiche della cute, questo rapporto si è riproposto sotto forme diverse ed in più ampia scala per l’elevatissima prevalenza dell’Ipovitaminosi D in molti Paesi, fra cui l’Italia, con conseguenti negativi effetti a livello scheletrico. La Vitamina D3 o colecalciferolo, una volta formatasi per effetto dei raggi UV, subisce una prima reazione di idrossilazione a livello epatico con formazione di [25(OH)D] che rappresenta l’indice dello status vitaminico D del soggetto e che, a livello plasmaticosi lega ad una proteina trasportatrice specifica (VitaminD bindingprotein) e subisce un’ulteriore idrossilazione a livello renale, con formazione di 1,25(OH)D (calcitriolo).

La Vitamina D così attivata promuove il riassorbimento di calcio a livello dei tubuli renali prossimali ed a livello intestinale e svolge funzioni endocrine, ma anche paracrine, agendo sulla differenziazione di alcune linee cellulari ed influenzando la forza muscolare. Sul metabolismo osseo agisce aumentando il livello di calcio plasmatico e riducendo i livelli di PTH ( paratormone )  sia indirettamente attraverso l’aumento dei livelli di calcio sia per azione diretta a livello delle paratiroidi. Alcuni dati sperimentali suggeriscono che la forma idrossilata della Vitamina D possa agire anche direttamente sulle cellule dell’osso agendo come regolatore dell’omeostasi fosfo-calcica e la sua cronica carenza si traduce da un lato in una maggiore attività osteoclastica conseguente all’incremento del PTH, e dall’altra in una più contenuta attività osteoblastica. Le conseguenze cliniche di questo fenomeno omeostatico, finalizzato al mantenimento di normali livelli plasmatici di calcio, sono la riduzione del BMD, una peggiore qualità dell’osso ed una maggiore incidenza di fratture.

Per prevenire i danni ossei prodotti dall’Ipovitaminosi D occorre mantenere i livelli plasmatici di Vitamina D superiori ai limiti che le linee guida di molti Paesi (LG SIOMMMS 2011) hanno definito in 30 ng/ml (75 nmol/l), se necessario ricorrendo alla sua supplementazione, atteso che gran parte degli anziani sono al di sotto, e talvolta marcatamente al di sotto di tali limiti. In effetti numerosi dati confermano i benefici effetti della Vitamina D, in associazione con il calcio,  nel ridurre l’incidenza delle fratture sia vertebrali che non vertebrali, nonché i suoi effetti sinergici positivi con i farmaci ad effetto antiriassorbitivo. In considerazione della sua frequente somministrazione in associazione a sali di calcio, non è raro osservare nella pratica clinica una scarsa aderenza nella sua assunzione a causa degli effetti collaterali imputabili essenzialmente al calcio: in questi casi occorre anzitutto valutare il fabbisogno di calcio in relazione all’intake alimentare della Paziente ed eventualmente somministrare la Vitamina D da sola oppure in associazione all’alendronato: l’obiettivo è in ogni caso quello di assicurare da un lato un apporto di Vitamina D sufficiente e dall’altro di somministrare correttamente i farmaci ricompresi nella Nota 79 ai Pazienti ad alto rischio fratturativo. Un positivo risultato del trattamento dell’osteoporosi verrà ottenuto somministrando sia farmaci antiriassorbitivi con dimostrate proprietà antifratturative, sia adeguate quantità di Vitamina D e, per quanto riguarda il calcio, le quantità minime indispensabili a colmare eventualmente il divario fra la quota assunta e quella raccomandata (1000-1200 mg/24h)

 

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