La longevità non dipende dai geni degli antenati ma dagli stili di vita

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Analizzata la banca dati di Ancestry su 400 milioni persone

Gli antenati avrebbero poco a che fare con la nostra longevita’: in una percentuale forse – secondo un nuovo studio Usa – addirittura inferiore al 10%.   Ad influire quindi con decisione sarebbero invece: stili di vita, ambiente naturale, scelta dei propri compagni di vita, dieta, movimento e cosi’ via. A sostenerlo e’ il piu’ vasto tentativo di analisi sull’ influenza della genetica in termini di durata di vita mai condotto: i dati provengono da circa 439 milioni di individui, che hanno utilizzato l’azienda di analisi genetiche Ancestry per risalire ai loro antenati.

Una joint-venture tra gli esperti di statistica di Ancestry e di Calico Life Sciences (azienda creata da Google) ha sezionato gli alberi genealogici di questi 400 milioni di individui, risalendo indietro generazioni, e includendo date di nascita, di morte, luoghi e legami familiari.   L’ influenza della genetica in comune sulla longevita’ individuale e’ quindi stata confrontata con l’ influenza sulla durata della vita tra non consanguinei: ad esempio tra sposi e persino tra cognati.  “Siamo riusciti a analizzare non solo famiglie attraverso generazioni e generazioni, ma ancor piu’ importante i dati genetici dei parenti non consanguinei”, ha osservato lo scienziato della Calico, Cathy Ball. I risultati indicano quindi che la longevita’ risulta a livello generale collegata al patrimonio genetico comune per meno del 10%. Se si includono i dati anche dei parenti non-consanguinei, l’influenza del Dna in comune scende addirittura al 7%.  Al contrario, la durata delle vita media appare piu’ simile tra sposi che vivono insieme una vita e tra cognati. Un dato sorprendente che secondo gli autori del rapporto, potrebbe dipendere dai cosiddetti ‘accoppiamenti selettivi’.Ossia alla tendenza tra fratelli e sorelle ad ‘accoppiarsi’ con partner dello stesso ‘fenotipo’: ossia di etnia , gusti, cultura, abitudini di vita, simili.    Il rapporto pubblicato sulla rivista specializzata ‘Genetics’ spiega nel dettaglio che l’influenza dei geni in comune appare piu’ marcata solo tra fratelli, sorelle e cugini di primo grado e dello stesso sesso: in questi casi il Dna comune puo’ influire per il 20%sulla durata della vita. Ma questa influenza scende al 15% tra fratelli, sorelle e cugini di primo grado di sesso opposto.

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